Tyres.co.uk features optional Michelin Pilot Sport 4 SUV and Pirelli P Zero in the size of 265/45 R20 108Y XL for the OE 20-inch wheels on the W166 ML63 AMG. These also fit the older W164 models as well as the W166 models with 21-inch wheels, but RHD and VIN confirmation is required before purchase.
ML63 AMG tyre size information with clearance can be found on the driver's door B-pillar placard as well as on the tyre load information placard. For information on correct tyre pressures, check the placard on the driver's side of the fuel filler door. Compare these placards to the sidewall of the tyres before purchase, as some variations of specific generations and some wheel sizes vary the factory size.
Most variants of the ML63 AMG do not require all four tyres replacing at once, but they all have a permanent 4MATIC four-wheel drive system. This means that the tyres must all be of the same type, brand and pattern, so all four must be replaced if a match cannot be kept. However, if only two new tyres are purchased, it is recommended to install them on the rear axle, in accordance with UK safety guidance.