Mercedes E63 AMG tyre options at Tyres.co.uk, in the stock staggered fitment for the 2020-2023 E 63 S 4MATIC+, are Michelin Pilot Sport 4 S and Pirelli P Zero (PZ4), which are 265/35 ZR20 on the front, 295/30 ZR20 on the back. Ensure registration, load and speed ratings along with construction type (XL) and Mercedes approvals are confirmed.
Tyre sizes for your Mercedes E63 AMG can be found on the driver side B-pillar placard. This can be viewed when the front door is opened. The placard lists the OEM sizes and load index, along with running pressure of the tyres. The tyre pressure table can be found on the inside of the fuel door, but for exact information on the specific vehicle the placard should be used.
Tyres for the Mercedes E63 AMG do not need to be replaced in sets of four. However, the E63 AMG 4MATIC+ does require that all 4 wheels have the same brand and type of tyre. A replacement of all 4 tyres is then required. In the UK, 2 front and 2 rear tyres can be fitted. Mode of recommendation is to retain the factory front to rear staggered arrangement.